Bentz et al. (2010) - Clinical relevance of IgG antibodies against food antigens in Crohn's disease: a double-blind cross-over diet intervention study

Bentz et al. (2010) - Clinical relevance of IgG antibodies against food antigens in Crohn's disease: a double-blind cross-over diet intervention study

Bentz et al. (2010) – Clinical relevance of IgG antibodies against food antigens in Crohn’s disease: a double-blind cross-over diet intervention study

Introduction – In this pilot study, 79 Crohn’s Disease patients and 20 healthy controls were examined for food specific immunoglobulin G (IgG). Thereafter, the clinical relevance of these food IgG antibodies was assessed in a double-blind cross-over study with 40 patients. Based on the IgG antibodies, a nutritional intervention was planned.

Summary – A nutritional intervention based on circulating IgG antibodies against food antigens showed effects with respect to stool frequency. Significant improvement in Crohn’s disease sufferers who followed diet removing food they showed sensitivity to (food sensitivity highlighted though IgG test). A clinically significant improvement in IBD symptoms was observed in patients eliminating foods to which they were found to exhibit sensitivity.

Bentz, S., Hausmann, M., Piberger, H., Kellermeier, S., Paul, S., Held, L., Falk, W., Obermeier, F., Fried, M., Schölmerich, J. and Rogler, G., 2010. Clinical relevance of IgG antibodies against food antigens in Crohn’s disease: a double-blind cross-over diet intervention study. Digestion, 81(4), pp.252-264.

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