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What Is the Blood Test Called for Gluten Intolerance?

Wondering what is the blood test called for gluten intolerance? Learn the difference between coeliac screening and IgG testing to identify your triggers today.
February 13, 2026

Table of Contents

  1. Introduction
  2. Decoding the Names: What Is the Blood Test Called?
  3. Understanding the "Big Three": Allergy vs. Intolerance vs. Coeliac
  4. The Smartblood Method: A Phased Approach to Wellness
  5. How the Smartblood Food Intolerance Test Works
  6. Is It Gluten, or Is It Something Else?
  7. Managing the Scientific Debate
  8. Taking Control of Your Health Journey
  9. FAQ
  10. Medical Disclaimer

Introduction

Have you ever finished a simple sandwich or a bowl of pasta, only to find yourself unbuttoning your jeans an hour later to accommodate a painfully distended stomach? Perhaps you experience a persistent "brain fog" or a slump in energy every afternoon that no amount of coffee can fix. In the UK, millions of us live with these "mystery symptoms," often suspecting that the culprit is gluten. However, when you approach a professional for help, the terminology can quickly become overwhelming. You might find yourself wondering: what is the blood test called for gluten intolerance, and which one do I actually need?

The confusion is understandable. If you search for answers, you are met with a dizzying array of acronyms like tTG, IgA, EMA, and IgG. Some of these tests are designed to find a serious autoimmune disease, while others look for signs that your body is simply struggling to process certain proteins. Understanding the difference is the first step toward reclaiming your digestive health and general well-being.

At Smartblood, we believe that true well-being comes from understanding the body as a whole, rather than just chasing isolated symptoms. This article will clarify the names of the various tests used to identify gluten-related issues, explain the crucial differences between coeliac disease and food intolerance, and guide you through a clinically responsible journey to finding answers.

Our "Smartblood Method" is built on a foundation of safety and clarity: we always recommend consulting your GP first to rule out serious conditions, followed by a structured elimination approach. If you are still seeking clarity, our Smartblood Food Intolerance Test can provide a helpful "snapshot" to guide your dietary choices and help you move away from the guesswork of trial and error.

Decoding the Names: What Is the Blood Test Called?

When people ask what is the blood test called for gluten intolerance, they are often looking for one of two things: a diagnosis of coeliac disease or an assessment of a non-coeliac gluten sensitivity (often referred to as food intolerance). It is vital to understand that these require different types of testing because they involve different parts of the immune system.

The Gold Standard for Coeliac Disease: tTG-IgA

If you visit your GP because you suspect gluten is making you ill, the first test they will likely order is the Tissue Transglutaminase (tTG) IgA test.

This is a serology test (a blood test that looks for antibodies). In people with coeliac disease, the immune system mistakenly treats gluten as a threat and produces antibodies that attack the lining of the small intestine. The tTG-IgA test is highly accurate at detecting these antibodies. However, for this test to work, you must be consuming gluten regularly; if you have already cut gluten out of your diet, the test may return a "false negative" because your antibody levels have dropped.

Checking for Deficiencies: Total IgA

Sometimes, a GP will also order a Total Serum IgA test. This isn’t a test for gluten specifically, but it checks if you have a general deficiency in IgA antibodies. If you are one of the few people who naturally produce very little IgA, the tTG-IgA test mentioned above won't work correctly, and the doctor will need to use different markers, such as tTG-IgG or DGP (Deamidated Gliadin Peptide) tests.

The "Double Check": EMA-IgA

The Endomysial Antibody (EMA) test is another blood test used to confirm a coeliac diagnosis. It is very specific, meaning it rarely gives a positive result unless the person truly has coeliac disease. Because it is more expensive and time-consuming for labs to process, it is often used as a secondary check if the tTG results are unclear.

Identifying Food Intolerance: The IgG Test

If your GP has ruled out coeliac disease but you still experience IBS and bloating when you eat bread or pasta, you may be looking for an IgG (Immunoglobulin G) food intolerance test.

While the coeliac tests look for an autoimmune reaction, an IgG test looks for "food-specific" antibodies that the body produces when it has difficulty processing certain proteins. At Smartblood, our Food Intolerance Test uses a highly sensitive method called ELISA (Enzyme-Linked Immunosorbent Assay) to measure IgG reactions to 260 different foods and drinks, including various grains that contain gluten.

Key Takeaway: If you suspect a serious medical condition, your GP will use tTG-IgA testing to look for coeliac disease. If you are looking to identify triggers for chronic discomfort, an IgG test is the tool often used to guide a structured elimination diet.

Understanding the "Big Three": Allergy vs. Intolerance vs. Coeliac

To choose the right path, you must understand what is happening inside your body. Not all reactions to gluten or wheat are the same, and some require much more urgent medical attention than others.

1. Food Allergy (The IgE Reaction)

A food allergy is typically an IgE-mediated response. This is the body’s "emergency" immune response. It usually happens very quickly—within seconds or minutes of eating the food.

Symptoms can include hives, swelling of the lips or face, and in severe cases, anaphylaxis. If you experience swelling of the throat, difficulty breathing, or feel like you are going to collapse after eating, you must call 999 or go to A&E immediately. A food intolerance test is not appropriate for these scenarios.

2. Coeliac Disease (The Autoimmune Reaction)

As discussed, coeliac disease is not an allergy or a simple intolerance; it is an autoimmune condition. When someone with coeliac disease eats gluten, their immune system attacks their own healthy tissue in the small intestine. Over time, this causes damage that prevents the body from absorbing nutrients, leading to fatigue, anaemia, and weight loss. It requires a formal medical diagnosis and a lifelong, strict gluten-free diet.

3. Food Intolerance (The IgG/Delayed Reaction)

Food intolerance, or sensitivity, is often much harder to pin down because the symptoms are "delayed." You might eat a piece of toast on Monday but not feel the migraine or the joint pain until Tuesday afternoon.

Because the reaction isn't life-threatening and doesn't show up on standard NHS coeliac screens, many people feel "dismissed" by the medical system. At Smartblood, our story began because we wanted to help people validate these very real, very frustrating "mystery symptoms."

The Smartblood Method: A Phased Approach to Wellness

We don't believe that testing should be your first port of call. Instead, we advocate for a clinically responsible, three-step journey to help you understand your body without jumping to conclusions.

Step 1: Consult Your GP First

Before you change your diet or buy a test, talk to your doctor. It is essential to rule out other causes for your symptoms, such as:

  • Coeliac disease (which requires specific NHS testing while you are still eating gluten).
  • Inflammatory Bowel Disease (IBD).
  • Thyroid issues or anaemia.
  • Side effects from medication.

Your GP is your partner in health. If they give you the "all-clear" but your symptoms persist, you can then move on to investigating food sensitivities.

Step 2: The Elimination Trial

The most "gold standard" way to identify a food trigger is an elimination diet. This involves removing suspected foods for several weeks and then systematically reintroducing them while tracking your symptoms.

To help with this, we provide a free food elimination diet chart. By keeping a diary, you might notice that it isn't just "gluten" causing the issue, but perhaps a combination of dairy and eggs or even yeast.

Step 3: Targeted Testing

If an elimination diet feels too overwhelming—or if you have tried it and still feel stuck—this is where Smartblood testing comes in. Rather than guessing which of the hundreds of foods in your diet is the problem, our test provides a "snapshot" of your IgG reactivity.

By identifying which foods your body is currently reacting to, you can create a much more targeted and effective elimination and reintroduction plan. It takes the guesswork out of the process, saving you months of frustration.

How the Smartblood Food Intolerance Test Works

If you decide that testing is the right next step for you, it’s helpful to know exactly what to expect. We have designed our process to be as simple and professional as possible.

  1. Order Your Kit: You can order the home finger-prick blood kit online.
  2. Take Your Sample: Follow the instructions to collect a small blood sample and post it back to our accredited laboratory in the provided packaging.
  3. Lab Analysis: Our specialists use ELISA technology to check for IgG antibodies against 260 different foods and drinks. You can see more about the evidence behind this on our Scientific Studies hub.
  4. Receive Your Results: Typically, within three working days of the lab receiving your sample, you will receive a detailed report via email.

Your results will show a reactivity scale from 0 to 5. A "0" means no reaction, while a "5" indicates a high level of IgG antibodies. This doesn't mean you can never eat that food again; it simply highlights which foods should be the focus of your initial elimination trial. For more practical details, you can visit our page on how it works.

Is It Gluten, or Is It Something Else?

One of the most common surprises for our customers is discovering that "gluten" isn't the only trigger. Wheat is a complex grain, and you might be reacting to specific proteins within the wheat, or perhaps to the yeast used to bake the bread.

Furthermore, many people who experience gut distress find they also have issues with dairy or even certain fruits. If you only test for gluten, you might miss the other factors that are contributing to your total "inflammation bucket."

For example, consider a scenario where someone feels sluggish and bloated every day. They assume it's the bread in their lunchtime sandwich. They cut out gluten but don't feel any better. Why? Because their Smartblood Food Intolerance Test later reveals a high reactivity to tomatoes and cow’s milk—the very things they were eating more of to replace the bread!

By looking at the body as a whole, you can stop the cycle of "diet hopping" and start a plan that is actually tailored to your unique biology.

Managing the Scientific Debate

It is important to be transparent: the use of IgG testing in food intolerance is a subject of ongoing debate within the medical community. Some organisations argue that IgG antibodies are a normal sign of food exposure rather than a sign of "intolerance."

At Smartblood, we frame our test not as a standalone diagnosis, but as a powerful tool to guide a structured elimination and reintroduction plan. We have seen thousands of customers find relief from chronic symptoms like skin problems and joint pain by using their IgG results as a roadmap.

Our goal is to empower you with information so that you can have a better-informed conversation with your GP or a nutritional professional. If you want to dive deeper into the research, we recommend reading our article on understanding the key differences between allergy and intolerance.

Taking Control of Your Health Journey

Living with "mystery symptoms" can be lonely and exhausting. When you don't know why your body is reacting, it’s easy to feel like you’ve lost control. Understanding what is the blood test called for gluten intolerance—and knowing which path to take—is the first step back to feeling like yourself again.

Remember the phased approach:

  1. Rule out the serious stuff with your GP (tTG-IgA for coeliac).
  2. Listen to your body by using an elimination diary.
  3. Refine your plan with a comprehensive Smartblood Food Intolerance Test if you need more clarity.

Whether your goal is fitness optimisation, better energy levels, or simply a day without bloating, we are here to support you. Our team is always available if you need to contact us with questions about the kit or your results.

Summary of Key Takeaways

  • tTG-IgA is the primary blood test used by GPs to screen for coeliac disease.
  • IgG Testing is used to identify potential food sensitivities that guide elimination diets.
  • Coeliac disease is an autoimmune condition; food intolerance is a delayed sensitivity; food allergy is a rapid, potentially severe immune response.
  • Always consult a GP before making major dietary changes, especially if you have severe symptoms.
  • A structured approach (GP first, then elimination, then testing) is the safest way to find lasting relief.

If you are ready to stop the guesswork and start understanding your triggers, the Smartblood Food Intolerance Test is available for £179.00. This comprehensive analysis of 260 foods and drinks provides the clarity you need to move forward. Plus, the discount code ACTION may be available on our site to give you 25% off your order.

Take the first step toward a clearer understanding of your body today.

Order your Smartblood Food Intolerance Test here.

FAQ

What is the difference between a coeliac test and an intolerance test?
A coeliac test (like tTG-IgA) looks for an autoimmune reaction that damages the small intestine. It is a medical diagnosis performed by the NHS. A food intolerance test (like the Smartblood IgG test) looks for delayed sensitivities to help you identify trigger foods for symptoms like bloating or fatigue. You can find more details on our FAQ page.

Do I need to be eating gluten for the test to work?
For a coeliac disease blood test, you must be eating gluten regularly for the results to be accurate. For our Smartblood IgG test, we generally recommend that you eat a normal, varied diet. If you have avoided a food for many months, your body may not be producing antibodies to it, which could lead to a low reactivity score on the report.

Can a blood test tell if I am allergic to wheat?
No. Our test is an IgG food intolerance test, not an IgE allergy test. If you suspect a rapid, severe allergy to wheat (e.g., hives, difficulty breathing), you must consult your GP for an allergy assessment or seek emergency care. For more on this, read our guide on unmasking food sensitivities.

How long does it take to get results?
Once your finger-prick sample reaches our lab, we typically provide your priority results via email within three working days. This allows you to start your targeted elimination plan almost immediately.

Medical Disclaimer

The information provided in this article is for educational and informational purposes only and does not constitute medical advice. Always consult your GP or a qualified healthcare professional before making any significant changes to your diet or lifestyle, especially if you are experiencing persistent or severe symptoms.

The Smartblood Food Intolerance Test is an IgG-based test designed to help guide a structured elimination and reintroduction diet. It is NOT a test for food allergies (IgE) and does not diagnose coeliac disease or any other medical condition.

If you experience symptoms of a severe allergic reaction—such as swelling of the lips, face, or throat, wheezing, difficulty breathing, or feeling faint—seek urgent medical help immediately by calling 999 or attending your nearest A&E.